Connexin43 and Bergmann glial gap junctions in cerebellar function
نویسندگان
چکیده
منابع مشابه
Connexin43 and Bergmann Glial Gap Junctions in Cerebellar Function
Connexin43 (Cx43), a major component of astrocytic gap junctions, is abundantly expressed in Bergmann glial cells (BGCs) in the cerebellum, but the function of Cx43 in BGCs is largely unknown. BGCs are specialized astrocytes closely associated with Purkinje cells. Here, we review our recent studies of the role of Cx43 in gap junctional coupling between BGCs and in cerebellar function. We genera...
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Gap junctions are plasma membrane areas enriched in channels that provide direct intercellular communication. Gap junctions have a high turnover rate; however, the mechanisms by which gap junctions are degraded are incompletely understood. In the present study, we show that in response to phorbol ester treatment, the gap junction channel protein Cx43 (connexin43) is redistributed from the plasm...
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ژورنال
عنوان ژورنال: frontiers in Neuroscience
سال: 2008
ISSN: 1662-4548
DOI: 10.3389/neuro.01.038.2008